{"id":35913,"date":"2018-12-12T15:31:32","date_gmt":"2018-12-12T17:31:32","guid":{"rendered":"https:\/\/nutritotal.com.br\/pro\/?p=35913"},"modified":"2023-05-31T13:50:26","modified_gmt":"2023-05-31T16:50:26","slug":"suplementacao-com-probioticos-atenua-danos-hepaticos","status":"publish","type":"post","link":"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/","title":{"rendered":"Suplementa\u00e7\u00e3o com Probi\u00f3ticos Atenua Danos Hep\u00e1ticos"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-35914\" src=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2019\/02\/esteatose2_novosite.png\" alt=\"\" width=\"1137\" height=\"501\" srcset=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2019\/02\/esteatose2_novosite.png 1137w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2019\/02\/esteatose2_novosite-300x132.png 300w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2019\/02\/esteatose2_novosite-1024x451.png 1024w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2019\/02\/esteatose2_novosite-768x338.png 768w\" sizes=\"(max-width: 1137px) 100vw, 1137px\" \/><\/p>\n<p>Won-Gyeong e sua equipe realizaram trabalho para avaliar os efeitos da suplementa\u00e7\u00e3o com \u00a0<i>Bifidobacterium longum<\/i>\u00a0LC67 e\u00a0<i>Lactobacillus plantarum<\/i>\u00a0LC27 sobre a esteatose hep\u00e1tica em ratos.<\/p>\n<p>A esteatose hep\u00e1tica foi induzida em ratos e estes foram divididos em 8 grupos: grupo controle (G1), adi\u00e7\u00e3o de glicose (G2), adi\u00e7\u00e3o de 100mg\/kg de silimarina (G3), LC27 10<sup>8<\/sup>\u00a0UFC 5x\/dia (G4), LC27 10<sup>9<\/sup>\u00a0UFC 2x\/dia (G5), LC67 10<sup>8<\/sup>\u00a0UFC 5x\/dia (G6), LC67 10<sup>9<\/sup>\u00a0UFC 2x\/dia (G7), e a mistura dos probi\u00f3ticos (MP) &#8211; LC27 10<sup>9<\/sup>\u00a0UFC 1x\/dia e LC67 10<sup>9<\/sup>\u00a0UFC 1x\/dia (G8). As suplementa\u00e7\u00f5es foram introduzidas no s\u00e9timo dia ap\u00f3s oferta de etanol e foram fornecidas durante 5 dias. Ap\u00f3s as interven\u00e7\u00f5es, as cobaias foram sacrificadas e foram colhidas amostras de sangue para an\u00e1lise de triglicer\u00eddeos (TG), colesterol total (TC), LDL, HDL, ALT, AST e gama-GT, e amostras teciduais do f\u00edgado e c\u00f3lon para an\u00e1lises histol\u00f3gicas e imunol\u00f3gicas, e dosagem de NF-\u03baB e TNF-\u03b1.<\/p>\n<p>A administra\u00e7\u00e3o oral de LC27, LC67 ou MP suprimiu o aumento de TG, TC, LDL, ALT, AST, gama-GT, TNF-\u03b1 e LPS induzido por etanol, e aumentou os n\u00edveis de HDL. \u00a0A suplementa\u00e7\u00e3o tamb\u00e9m suprimiu iNOS, a express\u00e3o de COX-2, a ativa\u00e7\u00e3o de NF-\u03baB, aumentou a ativa\u00e7\u00e3o da AMPK suprimida pelo etanol, e suprimiu significativamente a inflama\u00e7\u00e3o gastrintestinal induzida por etanol.<\/p>\n<p>A ingest\u00e3o de etanol alterou a composi\u00e7\u00e3o da microbiota intestinal. Foi observado aumentou de Firmicutes e Proteobacteria, e redu\u00e7\u00e3o de Bacteroidetes e Actinobacteria. O tratamento com os probi\u00f3ticos inibiu o crescimento de Proteobacterias e aumentou a popula\u00e7\u00e3o de Bacteroidetes e Actinobacteria.<\/p>\n<p id=\"yui_3_17_2_2_1549646123857_110\">Assim, os autores conclu\u00edram que a administra\u00e7\u00e3o oral de LC27 e \/ ou LC67 em camundongos suprimiu a atividade de mieloperoxidase, express\u00e3o de TNF-\u03b1 e ativa\u00e7\u00e3o de NF-\u03baB induzida por etanol no trato gastrointestinal. Em s\u00edntese, LC27 e LC67 podem atenuar a inflama\u00e7\u00e3o gastrintestinal induzida pelo etanol, a les\u00e3o hep\u00e1tica e esteatose, benef\u00edcios que podem estar associados \u00e0 \u00a0restaura\u00e7\u00e3o da microbiota intestinal.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Estudo com camundongos avaliou os benef\u00edcios da suplementa\u00e7\u00e3o com Bifidobacterium longum LC67 e Lactobacillus plantarum LC27 na Esteatose Hep\u00e1tica induzida por etanol<\/p>\n","protected":false},"author":15,"featured_media":35916,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1399],"tags":[120,121,105,119,641,118],"divisao":[2185,2186,2193],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Suplementa\u00e7\u00e3o com Probi\u00f3ticos Atenua Danos Hep\u00e1ticos - Nutritotal PRO<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Suplementa\u00e7\u00e3o com Probi\u00f3ticos Atenua Danos Hep\u00e1ticos\" \/>\n<meta property=\"og:description\" content=\"Estudo com camundongos avaliou os benef\u00edcios da suplementa\u00e7\u00e3o com Bifidobacterium longum LC67 e Lactobacillus plantarum LC27 na Esteatose Hep\u00e1tica induzida por etanol, e verificou que essa suplementa\u00e7\u00e3o pode atenuar a inflama\u00e7\u00e3o gastrintestinal induzida pelo etanol, a les\u00e3o hep\u00e1tica e esteatose, benef\u00edcios que podem estar associados \u00e0 restaura\u00e7\u00e3o da microbiota intestinal\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/\" \/>\n<meta property=\"og:site_name\" content=\"Nutritotal PRO\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/nutritotalPRO\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-12-12T17:31:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-31T16:50:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2019\/02\/esteatose2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1370\" \/>\n\t<meta property=\"og:image:height\" content=\"741\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Michelle Grillo Barone\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Michelle Grillo Barone\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/\"},\"author\":{\"name\":\"Michelle Grillo Barone\",\"@id\":\"https:\/\/nutritotal.com.br\/pro\/#\/schema\/person\/2edd7f2716a6ced17f76103a7b2875c4\"},\"headline\":\"Suplementa\u00e7\u00e3o com Probi\u00f3ticos Atenua Danos Hep\u00e1ticos\",\"datePublished\":\"2018-12-12T17:31:32+00:00\",\"dateModified\":\"2023-05-31T16:50:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/\"},\"wordCount\":365,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/nutritotal.com.br\/pro\/#organization\"},\"image\":{\"@id\":\"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2019\/02\/esteatose2_destaque.png\",\"keywords\":[\"esteatose\",\"f\u00edgado\",\"Obesidade\",\"probi\u00f3tico\",\"probi\u00f3ticos\",\"S\u00edndrome metab\u00f3lica\"],\"articleSection\":[\"Probi\u00f3ticos\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/\",\"url\":\"https:\/\/nutritotal.com.br\/pro\/suplementacao-com-probioticos-atenua-danos-hepaticos\/\",\"name\":\"Suplementa\u00e7\u00e3o com Probi\u00f3ticos Atenua Danos Hep\u00e1ticos - 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