{"id":39785,"date":"2019-04-29T16:51:12","date_gmt":"2019-04-29T19:51:12","guid":{"rendered":"https:\/\/nutritotal.com.br\/pro\/?p=39785"},"modified":"2023-03-24T16:43:15","modified_gmt":"2023-03-24T19:43:15","slug":"consumo-de-nozes-altera-proliferacao-e-morte-celular-no-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/nutritotal.com.br\/pro\/consumo-de-nozes-altera-proliferacao-e-morte-celular-no-cancer-de-mama\/","title":{"rendered":"Consumo de nozes altera prolifera\u00e7\u00e3o e morte celular no C\u00e2ncer de Mama"},"content":{"rendered":"

\"\"<\/p>\n

Estudo randomizado com \u00a0mulheres com c\u00e2ncer de mama avaliou a rela\u00e7\u00e3o entre consumo de nozes, crescimento tumoral, sobreviv\u00eancia de c\u00e9lulas cancer\u00edgenas e met\u00e1stase.<\/p>\n

10 mulheres com diagn\u00f3stico da doen\u00e7a foram divididas em grupo controle e grupo nozes. Ap\u00f3s realiza\u00e7\u00e3o de uma bi\u00f3psia, as mulheres do grupo nozes foram orientadas a consumir \u00a056,7g (m\u00e9dia de 11,36 unidades) de noz por dia. No ato cir\u00fargico, aproximadamente 2 semanas ap\u00f3s o in\u00edcio da interven\u00e7\u00e3o, amostras adicionais do tumor foram retiradas e avaliadas. Altera\u00e7\u00f5es na express\u00e3o g\u00eanica foram avaliadas comparando o per\u00edodo pr\u00e9 e p\u00f3s interven\u00e7\u00e3o.<\/p>\n

An\u00e1lise gen\u00e9tica revelou que a express\u00e3o de 456 genes foi significativamente alterada devido ao consumo de nozes. Observou-se ativa\u00e7\u00e3o de vias que promovem apoptose e ades\u00e3o celular, inibi\u00e7\u00e3o de vias que promovem prolifera\u00e7\u00e3o e migra\u00e7\u00e3o celular, redu\u00e7\u00e3o de inflama\u00e7\u00e3o e aumento da morte de celulas cancer\u00edgena no grupo que consumiu nozes. Tamb\u00e9m ocorreu supress\u00e3o da via PI3K\/Akt neste mesmo grupo, o que pode estar associado com melhor resposta \u00e0 quimioterapia.<\/p>\n

Os autores sugerem que ensaios cl\u00ednicos sejam realizados para confirmar os resultados positivos observados, mas destacam que o estudo apoia a hip\u00f3tese de que o consumo de nozes alteraria a express\u00e3o g\u00eanica em c\u00e2nceres de mama diminuindo crescimento e sobreviv\u00eancia do tumor. A incorpora\u00e7\u00e3o de nozes a uma dieta saud\u00e1vel pode reduzir a morbidade e mortalidade do c\u00e2ncer de mama.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Pesquisa avaliou o consumo de nozes durante 2 semanas em mulheres diagnosticadas com a doen\u00e7a, e observou altera\u00e7\u00e3o na express\u00e3o de 456 genes, com inibi\u00e7\u00e3o de vias associadas \u00e0 prolifera\u00e7\u00e3o celular, ativa\u00e7\u00e3o de vias associadas \u00e0 morte celular, e redu\u00e7\u00e3o da inflama\u00e7\u00e3o. <\/p>\n","protected":false},"author":112425,"featured_media":39802,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[147,788,930,932,90,185],"divisao":[2185,2186,3157],"acf":[],"yoast_head":"\nConsumo de nozes altera prolifera\u00e7\u00e3o e morte celular no C\u00e2ncer de Mama - Nutritotal PRO<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nutritotal.com.br\/pro\/consumo-de-nozes-altera-proliferacao-e-morte-celular-no-cancer-de-mama\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Consumo de nozes altera prolifera\u00e7\u00e3o e morte celular no C\u00e2ncer de Mama - Nutritotal PRO\" \/>\n<meta property=\"og:description\" content=\"Estudo realizado em mulheres com c\u00e2ncer de mama observou que o consumo de nozes (56,7g por dia - m\u00e9dia de 11,36 unidades- durante duas semanas) foi associado \u00e0 altera\u00e7\u00f5es na express\u00e3o de 456 genes, indicando ativa\u00e7\u00e3o de vias que promovem apoptose e ades\u00e3o celular, inibi\u00e7\u00e3o de vias que promovem prolifera\u00e7\u00e3o, redu\u00e7\u00e3o de inflama\u00e7\u00e3o, e aumento da morte celular cancer\u00edgena. 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