{"id":5051,"date":"2018-08-07T14:16:00","date_gmt":"2018-08-07T14:16:00","guid":{"rendered":"https:\/\/nutritotal.com.br\/pro?p=5051"},"modified":"2021-04-23T17:59:37","modified_gmt":"2021-04-23T20:59:37","slug":"gengibre-amargo-inibe-promoa-a-o-e-progressa-o-de-carcinoma-hepatocelular","status":"publish","type":"post","link":"https:\/\/nutritotal.com.br\/pro\/gengibre-amargo-inibe-promoa-a-o-e-progressa-o-de-carcinoma-hepatocelular\/","title":{"rendered":"Gengibre amargo inibe promo\u00e7\u00e3o e progress\u00e3o de Carcinoma Hepatocelular"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"img-responsive\" style=\"float: left;margin: 0 .5em 0 0\" role=\"presentation\" src=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2018\/08\/figado_site.jpg\" alt=\"\" width=\"300\" height=\"203\" \/>Zerumbona,um derivado da planta <i>Zingiber zerumbet<\/i>(Gengibre amargo), foi testado <i>in vitro<\/i>e <i>in vivo<\/i> por Wani e sua equipe para investigaros seus efeitos anti-HCC (carcinoma hepatocelular) e os mecanismos de a\u00e7\u00e3oenvolvidos nessa associa\u00e7\u00e3o. Para as an\u00e1lises <i>in vitro<\/i>, c\u00e9lulas humanas de HCC foram tratadas com diferentesconcentra\u00e7\u00f5es de Zerumbona. Nos testes <i>invivo<\/i>, ratos com HCC foram divididos em dois grupos &#8211; um recebeu inje\u00e7\u00f5es deHidroxipropil beta-Ciclodextrina (HPBCD), e outro recebeu inje\u00e7\u00f5es de Zerumbona(20 mg\/kg\/dia) durante 21 dias.<\/p>\n<p>A Zerumbonainibiu o potencial carcinog\u00eanico de c\u00e9lulas HCC por inibi\u00e7\u00e3o da progress\u00e3o dociclo celular e promo\u00e7\u00e3o de apoptose de maneira dose-dependente. Modulou aexpress\u00e3o de genes envolvidos no ciclo celular e apoptose, inibiu a express\u00e3ode genes regulados pelas vias de sinaliza\u00e7\u00e3o PI3K\/AKT\/mTOR e STAT3, reprogramouo metabolismo da glicose nestas c\u00e9lulas com redu\u00e7\u00e3o do consumo de glicose e daprodu\u00e7\u00e3o de lactato e bloqueio do ciclo celular, e regulou os genes envolvidosna glic\u00f3lise e na via das pentoses por inibi\u00e7\u00e3o da express\u00e3o de enzimas chaveque regulam esses processos.<\/p>\n<p>Nostestes <i>in vivo<\/i>, a Zerumbona retardouo crescimento das c\u00e9lulas tumorais e as met\u00e1stases associadas ao HCC.<\/p>\n<p>Osautores conclu\u00edram que a Zerumbona evita a tumorig\u00eanese hep\u00e1tica <i>in vitro<\/i> e <i>in vivo<\/i> atrav\u00e9s da regula\u00e7\u00e3o do metabolismo das c\u00e9lulas cancerosaspor bloqueio do ciclo celular e promo\u00e7\u00e3o da apoptose. Sugerem que componentesdiet\u00e9ticos, como a zerumbona, podem ser excelentes op\u00e7\u00f5es terap\u00eauticas para otratamento do HCC.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zerumbona,um derivado da planta Zingiber zerumbet(Gengibre amargo), foi testado in vitroe in vivo por Wani e sua equipe para investigaros seus efeitos anti-HCC (carcinoma hepatocelular) e os mecanismos de a\u00e7\u00e3oenvolvidos nessa associa\u00e7\u00e3o. Para as an\u00e1lises in vitro, c\u00e9lulas humanas de HCC foram tratadas com diferentesconcentra\u00e7\u00f5es de Zerumbona. Nos testes invivo, ratos com HCC foram divididos [&hellip;]<\/p>\n","protected":false},"author":44,"featured_media":5050,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"divisao":[2189],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gengibre amargo inibe promo\u00e7\u00e3o e progress\u00e3o de Carcinoma Hepatocelular - Nutritotal PRO<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nutritotal.com.br\/pro\/gengibre-amargo-inibe-promoa-a-o-e-progressa-o-de-carcinoma-hepatocelular\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gengibre amargo inibe promo\u00e7\u00e3o e progress\u00e3o de Carcinoma Hepatocelular - Nutritotal PRO\" \/>\n<meta property=\"og:description\" content=\"Zerumbona,um derivado da planta Zingiber zerumbet(Gengibre amargo), foi testado in vitroe in vivo por Wani e sua equipe para investigaros seus efeitos anti-HCC (carcinoma hepatocelular) e os mecanismos de a\u00e7\u00e3oenvolvidos nessa associa\u00e7\u00e3o. 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