{"id":54106,"date":"2022-04-18T11:41:00","date_gmt":"2022-04-18T14:41:00","guid":{"rendered":"https:\/\/nutritotal.com.br\/pro\/?p=54106"},"modified":"2022-06-03T09:59:57","modified_gmt":"2022-06-03T12:59:57","slug":"vitamina-b12-no-diabetes-tipo-2","status":"publish","type":"post","link":"https:\/\/nutritotal.com.br\/pro\/vitamina-b12-no-diabetes-tipo-2\/","title":{"rendered":"Suplementa\u00e7\u00e3o de \u00e1cido f\u00f3lico e vitamina B12 em pacientes com diabetes tipo 2"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_75 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Conte\u00fado<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabela de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/nutritotal.com.br\/pro\/vitamina-b12-no-diabetes-tipo-2\/#Intervencao_com_as_vitaminas_do_complexo_B\" >Interven\u00e7\u00e3o com as vitaminas do complexo B<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/nutritotal.com.br\/pro\/vitamina-b12-no-diabetes-tipo-2\/#Resultados\" >Resultados<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/nutritotal.com.br\/pro\/vitamina-b12-no-diabetes-tipo-2\/#B9_B12_ou_antidiabeticos\" >B9, B12 ou antidiab\u00e9ticos?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/nutritotal.com.br\/pro\/vitamina-b12-no-diabetes-tipo-2\/#Referencia\" >Refer\u00eancia<\/a><\/li><\/ul><\/nav><\/div>\n<p>O <a href=\"https:\/\/nutritotal.com.br\/pro\/material\/diretriz-de-diabetes-2019\/\" target=\"_blank\" rel=\"noopener\">diabetes<\/a> tipo 2 (DM2) \u00e9 uma doen\u00e7a metab\u00f3lica caracterizada por uma <a href=\"https:\/\/nutritotal.com.br\/pro\/o-que-a-e-como-se-desenvolve-resistaancia-a-insulina\/\" target=\"_blank\" rel=\"noopener\">resist\u00eancia \u00e0 insulina<\/a> ou uma redu\u00e7\u00e3o nos n\u00edveis desse horm\u00f4nio circulante no sangue, o que eleva a glicemia do paciente diab\u00e9tico. Ela est\u00e1 associada, tamb\u00e9m, a um pior perfil lip\u00eddico e um ac\u00famulo de gordura visceral.<\/p>\n<div id=\"attachment_54107\" style=\"width: 1150px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-54107\" class=\"wp-image-54107 size-full\" src=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2022\/04\/B12_site.png\" alt=\"vitamina b12 no diabetes tipo 2\" width=\"1140\" height=\"460\" srcset=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2022\/04\/B12_site.png 1140w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2022\/04\/B12_site-300x121.png 300w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2022\/04\/B12_site-1024x413.png 1024w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2022\/04\/B12_site-768x310.png 768w\" sizes=\"(max-width: 1140px) 100vw, 1140px\" \/><p id=\"caption-attachment-54107\" class=\"wp-caption-text\">Fonte: Shutterstock<\/p><\/div>\n<p>Por isso, para o tratamento dessa condi\u00e7\u00e3o as orienta\u00e7\u00f5es s\u00e3o fazer <a href=\"https:\/\/nutritotal.com.br\/pro\/diabetes-tipo-2-efeitos-de-uma-dieta-personalizada\/\" target=\"_blank\" rel=\"noopener\">escolhas alimentares<\/a> focadas em alimentos menos processados e mais <a href=\"https:\/\/nutritotal.com.br\/pro\/consumo-de-suco-de-frutas-e-frutas-e-incidencia-de-diabetes-tipo-2\/\" target=\"_blank\" rel=\"noopener\"><em>in natura<\/em><\/a>, al\u00e9m de praticar atividade f\u00edsica. Essas mudan\u00e7as auxiliam no controle glic\u00eamico e na redu\u00e7\u00e3o \u00e0 resist\u00eancia insul\u00ednica, prorrogando o uso de medicamentos hipoglicemiantes ou mesmo da insulina.<\/p>\n<p>Pensando em outras estrat\u00e9gias, segundo estudos, a suplementa\u00e7\u00e3o com determinadas vitaminas do complexo B, auxiliam no tratamento da diabetes. O <a href=\"https:\/\/nutritotal.com.br\/pro\/serie-micronutrientes-qual-e-a-importancia-do-acido-folico\/\" target=\"_blank\" rel=\"noopener\">\u00e1cido f\u00f3lico<\/a> parece melhorar o controle glic\u00eamico em indiv\u00edduos com diabetes tipo 2, enquanto a <a href=\"https:\/\/nutritotal.com.br\/pro\/beneficios-da-suplementacao-com-a-vitamina-b12-na-forma-de-metilcobalamina\/\" target=\"_blank\" rel=\"noopener\">vitamina B12<\/a> possibilita a melhora da toler\u00e2ncia \u00e0 glicose.<\/p>\n<p>Considerando os achados de pesquisas que trazem esses pareceres, um novo estudo se prop\u00f4s a investigar e comparar os efeitos da suplementa\u00e7\u00e3o de \u00e1cido f\u00f3lico e <a href=\"https:\/\/nutritotal.com.br\/pro\/material\/tabela-de-teor-de-vitamina-b12-nos-alimentos\/\" target=\"_blank\" rel=\"noopener\">vitamina B12<\/a> no controle glic\u00eamico, na <a href=\"https:\/\/nutritotal.com.br\/pro\/dieta-resistencia-a-insulina\/\" target=\"_blank\" rel=\"noopener\">resist\u00eancia \u00e0 insulina<\/a> e no perfil lip\u00eddico s\u00e9rico de pacientes com diabetes tipo 2.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Intervencao_com_as_vitaminas_do_complexo_B\"><\/span><strong>Interven\u00e7\u00e3o com as vitaminas do complexo B<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Oitenta pacientes com idade entre 30 e 65 anos, portadores de diabetes tipo 2 e sob uso de hipoglicemiantes orais, foram convidados a participar desse estudo que teve dura\u00e7\u00e3o de 8 semanas. Eles foram divididos igualmente em quatro grupos:<\/p>\n<p><strong>Grupo A:<\/strong> recebeu suplementa\u00e7\u00e3o de \u00e1cido f\u00f3lico + antidiab\u00e9ticos orais<\/p>\n<p><strong>Grupo B:<\/strong> recebeu suplementa\u00e7\u00e3o de vitamina B12 + antidiab\u00e9ticos orais<\/p>\n<p><strong>Grupo C:<\/strong> recebeu suplementa\u00e7\u00e3o de \u00e1cido f\u00f3lico + vitamina B12 + antidiab\u00e9ticos orais<\/p>\n<p><strong>Grupo D:<\/strong> recebeu apenas antidiab\u00e9ticos orais<\/p>\n<p>No in\u00edcio do estudo e ao final das oito semanas, os participantes ficaram 12h em jejum para que fossem coletadas amostras de sangue e dados sobre peso corporal, altura, press\u00e3o arterial e circunfer\u00eancia da cintura. Com as amostras de sangue foram avaliadas a glicemia, hemoglobina glicada, n\u00edveis de insulina, perfil lip\u00eddico, homociste\u00edna s\u00e9rica, adiponectina s\u00e9rica (horm\u00f4nio relacionado \u00e0 sensibiliza\u00e7\u00e3o da insulina), fator de necrose tumoral s\u00e9rica, interleucina s\u00e9rica e prote\u00edna C reativa. A resist\u00eancia \u00e0 insulina foi calculada usando o modelo de homeostase HOMA-2.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Resultados\"><\/span><strong>Resultados<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Comparando as an\u00e1lises dos 4 grupos, a hemoglobina glicada apresentou melhora significativa nos grupos B (- 1,2%) e C (-1,5%), enquanto o grupo A reduziu apenas 0,8 % e o grupo D n\u00e3o reduziu. B e C tamb\u00e9m mostraram melhora da insulina plasm\u00e1tica (-4,1 e -4,4 \u03bcU\/mL), da resist\u00eancia \u00e0 insulina (-1,3 e \u2013 1,5) e da sensibilidade \u00e0 insulina, representada por valores elevados de adiponectina (7,4 e 6,2 ng\/mL).<\/p>\n<p>Os grupos A e D tiveram resultados pouco relevantes em rela\u00e7\u00e3o a esses par\u00e2metros, por\u00e9m, tanto o grupo A quanto B e C, apresentaram redu\u00e7\u00e3o da <a href=\"https:\/\/nutritotal.com.br\/pro\/qual-a-relaa-a-o-entre-homocistea-na-a-cido-fa-lico-e-vitamina-b12\/\" target=\"_blank\" rel=\"noopener\">homociste\u00edna<\/a>, indicando menor risco de doen\u00e7as cardiovasculares. O perfil lip\u00eddico n\u00e3o teve altera\u00e7\u00f5es consider\u00e1veis nos quatro grupos.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"B9_B12_ou_antidiabeticos\"><\/span><strong>B9, B12 ou antidiab\u00e9ticos?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>A partir desses resultados, os pesquisadores consideraram que a suplementa\u00e7\u00e3o de B12 e \u00e1cido f\u00f3lico apresenta efic\u00e1cia na melhora dos par\u00e2metros de aten\u00e7\u00e3o relacionados \u00e0 diabetes tipo 2. Diferentemente dos antidiab\u00e9ticos orais, a <a href=\"https:\/\/nutritotal.com.br\/pro\/a-cido-fa-lico-e-vitamina-b12-previnem-decla-nio-cognitivo-em-idosos\/\" target=\"_blank\" rel=\"noopener\">suplementa\u00e7\u00e3o dessas duas vitaminas<\/a>, principalmente combinadas, apoia o controle glic\u00eamico, evitando situa\u00e7\u00f5es de hiperglicemia ou complica\u00e7\u00f5es associadas \u00e0 doen\u00e7a.<\/p>\n<p><strong>Veja, com o nutricionista Moises Pinheiro, como utilizar essas informa\u00e7\u00f5es na pr\u00e1tica:<\/strong><\/p>\n<p><iframe loading=\"lazy\" title=\"Suplementa\u00e7\u00e3o de \u00e1cido f\u00f3lico e vitamina B12 em pacientes com diabetes tipo 2\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/UrViNRC7dSI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Referencia\"><\/span><strong>Refer\u00eancia<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Swayamjeet Satapathy, Debapriya Bandyopadhyay, Binod Kumar Patro, Shahnawaz Khan, Sanjukta Naik, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0965229920306610?via%3Dihub\" target=\"_blank\" rel=\"noopener\"><strong>Folic acid and vitamin B12 supplementation in subjects with type 2 diabetes mellitus: A multi-arm randomized controlled clinical trial<\/strong><\/a>, Complementary Therapies in Medicine, Volume 53, 2020, 102526, ISSN 0965-2299, https:\/\/doi.org\/10.1016\/j.ctim.2020.102526.<\/p>\n<p>&nbsp;<\/p>\n<p>Parceria:<\/p>\n<p><a href=\"https:\/\/www.bariatricfusion.com.br\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-54117\" src=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2022\/04\/logo_fusion.png\" alt=\"\" width=\"145\" height=\"87\" srcset=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2022\/04\/logo_fusion.png 211w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2022\/04\/logo_fusion-200x122.png 200w\" sizes=\"(max-width: 145px) 100vw, 145px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>O diabetes tipo 2 (DM2) \u00e9 uma doen\u00e7a metab\u00f3lica caracterizada por uma resist\u00eancia \u00e0 insulina ou uma redu\u00e7\u00e3o nos n\u00edveis desse horm\u00f4nio circulante no sangue, o que eleva a glicemia do paciente diab\u00e9tico. Ela est\u00e1 associada, tamb\u00e9m, a um pior perfil lip\u00eddico e um ac\u00famulo de gordura visceral. Por isso, para o tratamento dessa condi\u00e7\u00e3o [&hellip;]<\/p>\n","protected":false},"author":112426,"featured_media":54108,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1328],"tags":[519,211,1284,440,1212,534],"divisao":[2185,2186],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>vitamina b12 no diabetes tipo 2<\/title>\n<meta name=\"description\" content=\"Estudo avalia os efeitos da suplementa\u00e7\u00e3o de de \u00e1cido f\u00f3lico e vitamina B12 no controle glic\u00eamico e na resist\u00eancia \u00e0 insulina de pacientes com diabetes tipo 2\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nutritotal.com.br\/pro\/vitamina-b12-no-diabetes-tipo-2\/\" \/>\n<meta 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