{"id":64536,"date":"2024-08-21T10:00:51","date_gmt":"2024-08-21T13:00:51","guid":{"rendered":"https:\/\/nutritotal.com.br\/pro\/?p=64536"},"modified":"2024-09-10T16:14:39","modified_gmt":"2024-09-10T19:14:39","slug":"omega-3-em-np-aprimora-recuperacao-pos-operatoria-em-doenca-de-crohn","status":"publish","type":"post","link":"https:\/\/nutritotal.com.br\/pro\/omega-3-em-np-aprimora-recuperacao-pos-operatoria-em-doenca-de-crohn\/","title":{"rendered":"\u00d4mega-3 em NP aprimora recupera\u00e7\u00e3o p\u00f3s-operat\u00f3ria em doen\u00e7a de Crohn"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_75 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Conte\u00fado<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabela de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/nutritotal.com.br\/pro\/omega-3-em-np-aprimora-recuperacao-pos-operatoria-em-doenca-de-crohn\/#Metodologia_da_pesquisa\" >Metodologia da pesquisa<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/nutritotal.com.br\/pro\/omega-3-em-np-aprimora-recuperacao-pos-operatoria-em-doenca-de-crohn\/#Omega-3_em_NP_melhorou_resultados_pos-operatorios\" >\u00d4mega-3 em NP melhorou resultados p\u00f3s-operat\u00f3rios<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/nutritotal.com.br\/pro\/omega-3-em-np-aprimora-recuperacao-pos-operatoria-em-doenca-de-crohn\/#Conclusao\" >Conclus\u00e3o<\/a><\/li><\/ul><\/nav><\/div>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/nutritotal.com.br\/pro\/recomendacoes-nutricionais-na-doenca-de-crohn\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">doen\u00e7a de Crohn<\/span><\/a><span style=\"font-weight: 400;\"> (DC) \u00e9 uma doen\u00e7a inflamat\u00f3ria intestinal cr\u00f4nica (DII) incur\u00e1vel. Para o seu tratamento, o principal alvo \u00e9 inibir a inflama\u00e7\u00e3o desenfreada do trato gastrointestinal.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Grande parte dos pacientes com DC necessitam de interven\u00e7\u00e3o cir\u00fargica. Contudo, muitos deles n\u00e3o conseguem atingir suas metas energ\u00e9ticas p\u00f3s-cir\u00fargicas por via enteral, necessitando do suporte da nutri\u00e7\u00e3o parenteral.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sabendo que os \u00e1cidos graxos \u00f4mega-3 demonstram um importante papel anti-inflamat\u00f3rio, um novo estudo cient\u00edfico investigou a suplementa\u00e7\u00e3o deste nutriente em pacientes com DC no p\u00f3s-operat\u00f3rio. Os resultados foram animadores! Confira a seguir.<\/span><\/p>\n<div id=\"attachment_64539\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-64539\" class=\"wp-image-64539 size-large\" src=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2024\/08\/portal-para-nutricionistas-omega-3-em-np-1024x410.png\" alt=\"\u00f4mega-3 em NP\" width=\"1024\" height=\"410\" srcset=\"https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2024\/08\/portal-para-nutricionistas-omega-3-em-np-1024x410.png 1024w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2024\/08\/portal-para-nutricionistas-omega-3-em-np-300x120.png 300w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2024\/08\/portal-para-nutricionistas-omega-3-em-np-768x307.png 768w, https:\/\/nutritotal.com.br\/pro\/wp-content\/uploads\/2024\/08\/portal-para-nutricionistas-omega-3-em-np.png 1150w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-64539\" class=\"wp-caption-text\">Fonte: Canva<\/p><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Metodologia_da_pesquisa\"><\/span><b>Metodologia da pesquisa<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Recentemente, pesquisadores chineses conduziram um ensaio cl\u00ednico prospectivo randomizado e n\u00e3o cego. Ao total, foram inclu\u00eddos 234 pacientes com doen\u00e7a de Crohn, submetidos \u00e0 ressec\u00e7\u00e3o intestinal e com risco nutricional.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Os pacientes foram divididos igualmente em 2 grupos:<\/span><\/p>\n<ol>\n<li><b> Grupo de tratamento<\/b><span style=\"font-weight: 400;\">: receberam NP com gorduras de cadeia longa, m\u00e9dia e poli-insaturadas n\u20133 a 1,2 g\/kg\/d (durante 5 dias).<\/span><\/li>\n<li><b> Grupo controle<\/b><span style=\"font-weight: 400;\">: receberam NP com uma mistura de gorduras de cadeia longa e m\u00e9dia a 1,0 g\/kg\/d.<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">Em seguida, os grupos foram comparados quanto:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Complica\u00e7\u00f5es p\u00f3s-operat\u00f3rias (desfecho prim\u00e1rio)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hemograma completo (desfecho secund\u00e1rio)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Valores bioqu\u00edmicos s\u00e9ricos (desfecho secund\u00e1rio)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Concentra\u00e7\u00f5es de citocinas (desfecho secund\u00e1rio)<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Omega-3_em_NP_melhorou_resultados_pos-operatorios\"><\/span><b>\u00d4mega-3 em NP melhorou resultados p\u00f3s-operat\u00f3rios<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Ap\u00f3s a an\u00e1lise extensa dos dados, os autores notaram uma redu\u00e7\u00e3o significativa nas taxas gerais de complica\u00e7\u00f5es (22,4% vs. 49,3% na an\u00e1lise de inten\u00e7\u00e3o de tratar e 21,8% vs. 38,2% na an\u00e1lise por protocolo).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Al\u00e9m disso, a perman\u00eancia hospitalar p\u00f3s-operat\u00f3ria tamb\u00e9m diminuiu no grupo suplementado com <\/span><a href=\"https:\/\/nutritotal.com.br\/pro\/material\/uso-clinico-de-omega-3-via-parenteral\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">\u00f4mega-3<\/span><\/a><span style=\"font-weight: 400;\"> (8,8 vs. 11,2 dias na an\u00e1lise de inten\u00e7\u00e3o de tratar, e 8,7 vs. 11,5 na an\u00e1lise por protocolo).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nos resultados secund\u00e1rios, diversos par\u00e2metros bioqu\u00edmicos relacionados \u00e0 inflama\u00e7\u00e3o tamb\u00e9m foram menores para o grupo suplementado, no 5\u00ba dia p\u00f3s-operat\u00f3rio. Foram eles:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Interleucina (IL)-6 (17,11 pg\/mL vs. 30,50 pg\/mL)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Interleucina IL-1\u03b2 (2,01 pg\/mL vs. 2,24 pg\/mL)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fator de necrose tumoral-\u03b1 (2,09 pg\/mL vs. 2,29 pg\/mL)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Concentra\u00e7\u00f5es de prote\u00edna C-reativa (51,3 mg\/L vs. 64,4 mg\/L)<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Conclusao\"><\/span><b>Conclus\u00e3o<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Em resumo, a suplementa\u00e7\u00e3o parenteral de \u00f4mega-3 melhorou os resultados p\u00f3s-operat\u00f3rios para pacientes com doen\u00e7a de Crohn ap\u00f3s ressec\u00e7\u00e3o intestinal, reduzindo a taxa de complica\u00e7\u00f5es e a perman\u00eancia hospitalar.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Al\u00e9m disso, tamb\u00e9m reduziu significativamente as citocinas inflamat\u00f3rias, incluindo as concentra\u00e7\u00f5es de IL-1\u03b2, IL-6, TNF-\u03b1 e PCR.<\/span><\/p>\n<p><b>Para ler o artigo cient\u00edfico completo, <\/b><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38569774\/\" target=\"_blank\" rel=\"noopener\"><b>clique aqui<\/b><\/a><b>.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Se voc\u00ea gostou deste conte\u00fado, leia tamb\u00e9m:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/nutritotal.com.br\/pro\/material\/uso-clinico-de-omega-3-via-parenteral\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Posicionamento BRASPEN: uso de \u00f4mega-3 via parenteral<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/nutritotal.com.br\/pro\/omega-3-quais-os-beneficios-para-a-saude\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">\u00d4mega-3: quais os benef\u00edcios para a sa\u00fade?<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/nutritotal.com.br\/pro\/o-nutricionista-pode-prescrever-nutria-a-o-parenteral\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">O nutricionista pode prescrever nutri\u00e7\u00e3o parenteral?<\/span><\/a><\/li>\n<\/ul>\n<p><b>Refer\u00eancia:<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Ge X, Liu H, Wu Y, Liu W, Qi W, Ye L, Cao Q, Lian H, Bai R, Zhou W. <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38569774\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Parenteral n-3 polyunsaturated fatty acids supplementation improves postoperative recovery for patients with Crohn&#8217;s disease after bowel resection: a randomized, unblinded controlled clinical trial<\/span><\/a><span style=\"font-weight: 400;\">. Am J Clin Nutr. 2024 Apr;119(4):1027-1035. doi: 10.1016\/j.ajcnut.2023.12.022. Epub 2024 Feb 19. PMID: 38569774.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A doen\u00e7a de Crohn (DC) \u00e9 uma doen\u00e7a inflamat\u00f3ria intestinal cr\u00f4nica (DII) incur\u00e1vel. Para o seu tratamento, o principal alvo \u00e9 inibir a inflama\u00e7\u00e3o desenfreada do trato gastrointestinal.\u00a0 Grande parte dos pacientes com DC necessitam de interven\u00e7\u00e3o cir\u00fargica. Contudo, muitos deles n\u00e3o conseguem atingir suas metas energ\u00e9ticas p\u00f3s-cir\u00fargicas por via enteral, necessitando do suporte da [&hellip;]<\/p>\n","protected":false},"author":114981,"featured_media":64538,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2959],"tags":[320,328,98,317],"divisao":[2185,3327],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00d4mega-3 em NP aprimora recupera\u00e7\u00e3o p\u00f3s-operat\u00f3ria em doen\u00e7a de Crohn<\/title>\n<meta name=\"description\" content=\"Nova pesquisa sugere que a suplementa\u00e7\u00e3o com \u00f4mega-3 em NP (nutri\u00e7\u00e3o parenteral) pode ser ben\u00e9fica para pacientes com doen\u00e7a de Chron.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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